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{"id":1508,"date":"2019-10-12T02:45:07","date_gmt":"2019-10-12T06:45:07","guid":{"rendered":"http:\/\/zuaadc.org\/?p=1508"},"modified":"2019-10-14T15:42:47","modified_gmt":"2019-10-14T19:42:47","slug":"wangguangliang-2","status":"publish","type":"post","link":"https:\/\/zuaadc.org\/2019\/10\/12\/wangguangliang-2\/","title":{"rendered":"\u5c42\u5c42\u63ed\u79d8\u7559\u7f8e\u534e\u4eba\u5bf9\u8bfa\u5956\u7684\u539f\u521b\u8d21\u732e\uff0cget\u5230\u4e86\u5417\uff1f"},"content":{"rendered":"

<\/p>

\u2014\u2014\u6df1\u5ea6\u91c7\u8bbf\u544a\u8bc9\u4f60\u738b\u5e7f\u826f\u535a\u58eb\u662f\u5982\u4f55\u5960\u5b9a2019\u8bfa\u8d1d\u5c14\u751f\u7406\u533b\u5b66\u5956\u7684\u6838\u5fc3\u57fa\u7840
<\/p>

(\u8d75\u541b \u534e\u76db\u987f \u62a5\u5bfc)
<\/p>

2019\u5e74\u5ea6\u8bfa\u8d1d\u5c14\u79d1\u5b66\u5956\u9879\u5168\u90e8\u5f00\u51fa\uff0c\u4e2d\u56fd\u5b66\u8005\u4e0d\u51fa\u610f\u5916\uff0c\u518d\u6b21\u65e0\u7f18\u3002\u56db\u5341\u5e74\u6765\uff0c\u4e2d\u56fd\u793e\u4f1a\u9ad8\u901f\u53d1\u5c55\uff0c\u79d1\u6280\u8fc5\u901f\u524d\u8fdb\u3002\u800c\u8fd1\u5e74\u6765\uff0c\u56fd\u5185\u7eb7\u7eb7\u6518\u6518\u5ba3\u4f20\u7684\u201c\u8bfa\u5956\u7ea7\u6210\u679c\u201d\u5c1a\u6709\u5f85\u65f6\u95f4\u7684\u8003\u9a8c\u3002\u4eca\u5929\uff0c\u6211\u4eec\u56f4\u89c2\u8bfa\u5956\uff0c\u4e0e\u5176\u7a7a\u8c08\u5f71\u54cd\u56e0\u5b50\uff0c\u5e7b\u60f3\u5f2f\u9053\u8d85\u8f66\uff0c\u4e0d\u5982\u9759\u4e0b\u5fc3\u6765\u54c1\u5473\u771f\u6b63\u7684\u8bfa\u5956\u6210\u679c\u7684\u6700\u521d\u8bde\u751f\u65f6\u523b\u3002\u4ece\u96f6\u5230\u4e00\u8fd9\u4e2a\u8fc7\u7a0b\uff0c\u662f\u5982\u4f55\u5e72\u51fa\u6765\u7684\uff01\uff1f
<\/p>

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<\/p>

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<\/p>

Semenza\u6559\u6388\u5728Cell\u6742\u5fd7\u56de\u5fc6\u6587\u7ae0\u4e2d\u7684\u4e5d\u5bab\u683c\u7167\u7247
<\/figcaption><\/figure>
<\/p>
\u4e3a\u4ec0\u4e48\u662f\u738b\u5e7f\u826f\uff1f<\/strong>
<\/p>
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<\/p>
\u8ba9\u6211\u4eec\u628a\u76ee\u5149\u8f6c\u56de\u523028\u5e74\u524d\u7684\u90a3\u4e2a\u51ac\u5929\uff0c\u770b\u770b\u3002\u5e74\u8f7b\u7684Gregg Semenza \u535a\u58eb\u62ff\u5230\u4e86\u4e24\u9879\u79d1\u7814\u57fa\u91d1\uff0c\u5728\u8457\u540d\u7684Johns Hopkins \u5927\u5b66\u6210\u4e3a\u4e86\u52a9\u7406\u6559\u6388\uff0c\u65b0\u5f00\u4e86\u5c5e\u4e8e\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u66fe\u8bf4\u8fc7\u4ed6\u8fd9\u662f\u6781\u7aef\u7684\u5e78\u8fd0(extremely fortunate) \u3002\u7136\u800c\u4ed6\u5f53\u65f6\u6ca1\u6599\u5230\u662f\uff0c\u66f4\u5927\u7684\u8fd0\u6c14\u8fd8\u4f1a\u964d\u4e34\u5230\u4ed6\u8eab\u4e0a\u3002\u4ed6\u62db\u5230\u4e86\u4ed6\u804c\u4e1a\u751f\u6daf\u4e2d\u7684\u7b2c\u4e00\u4e2a\u535a\u58eb\u540e\uff0c\u540e\u6765\u88ab\u4ed6\u53cd\u590d\u79f0\u8d5e\u4e3a\u6770\u51fa\u79d1\u5b66\u5bb6(fabulous scientist) \u7684\u738b\u5e7f\u826f\u535a\u58eb\u3002
<\/p>
1992\u5e741\u6708\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u6b63\u5f0f\u52a0\u76dfSemenza \u5b9e\u9a8c\u5ba4\uff0c\u5171\u540c\u641c\u5bfb\u90a3\u4e2a\u80fd\u611f\u77e5\u6c27\u6c14\uff0c\u8c03\u8282\u8840\u7ea2\u7ec6\u80de\u751f\u6210\u7d20EPO\u7684\u795e\u79d8\u5e7d\u7075\u3002\u4e00\u95f4\u5c0f\u5c0f\u7684\u5b9e\u9a8c\u5ba4\uff0c\u51e0\u4e2a\u8001\u65e7\u4eea\u5668\uff0c\u4e00\u4e2a\u7565\u663e\u7a1a\u5ae9\u7684\u5e74\u8f7b\u6559\u6388\uff0c\u4e00\u4e2a\u5145\u6ee1\u5e72\u52b2\u7684\u65b0\u79d1\u535a\u58eb\uff0c\u5728\u90a3\u4e2a\u5bd2\u51ac\u5c31\u5168\u529b\u542f\u52a8\u4e86\u3002\u738b\u5e7f\u826f\u535a\u58eb\u81f3\u4eca\u8fd8\u8bb0\u5f97\u6700\u521d\u4e00\u4e24\u4e2a\u6708\u7684\u65f6\u5149\uff0c\u7ecf\u5e38\u6027\u7684\u501f\u522b\u4eba\u7684\u4eea\u5668\u501f\u4e0d\u5230\uff0c\u5b9e\u9a8c\u5ba4\u5c31\u53ea\u6709\u4ed6\u4eec\u5e08\u5f92\u4e8c\u4eba\u3002\u6ca1\u6709\u5b9e\u9a8c\uff0c\u4ed6\u4fe9\u4fbf\u5728\u5b9e\u9a8c\u53f0\u524d\u7528\u7eb8\u7b14\u89c4\u5212\u7740\u5b9e\u9a8c\u548c\u65f6\u95f4\uff0c\u4e24\u4eba\u751a\u81f3\u4e3a\u4e86\u5bf9\u7167\u5b9e\u9a8c\u548c\u68c0\u6d4b\u65b9\u6848\u4e89\u8bba\u7684\u9762\u7ea2\u8033\u8d64\u3002\u6b63\u662f\u8fd9\u6bb5\u4e0d\u5bb9\u6613\u52a8\u624b\u505a\u5b9e\u9a8c\u7684\u65f6\u5149\uff0c\u953b\u9020\u4e86\u4e25\u8c28\u7684\u79d1\u7814\u89c4\u5212\u548c\u5b9e\u9a8c\u65b9\u6848\u3002\u6b63\u662f\u8fd9\u6837\u53cd\u590d\u7684\u8fa8\u6790\uff0c\u738b\u5e7f\u826f\u5bf9\u641c\u5bfb\u6c27\u611f\u77e5\u56e0\u5b50\u6709\u4e86\u7cfb\u7edf\u6027\u7684\u601d\u8003\uff0c\u4f7f\u5f97\u4ed6\u5728\u4ee5\u540e\u7684\u5b9e\u9a8c\u4e2d\u8033\u806a\u76ee\u660e\uff0c\u5fc3\u7075\u624b\u5de7\uff0c\u4ee5\u6700\u5c11\u7684\u8bef\u64cd\u4f5c\uff0c\u8fc5\u901f\u6210\u529f\u3002
<\/p>
\u738b\u5e7f\u826f\u535a\u58eb\u540e\u6765\u603b\u7ed3\uff0c\u4e00\u95e8\u5fc3\u601d\u7684\u82e6\u5e72\uff0c\u4e5f\u662f\u539f\u521b\u6027\u5de5\u4f5c\u5fc5\u987b\u7684\u3002\u867d\u7136\u738b\u5e7f\u826f\u5728\u4e2d\u56fd\u8457\u540d\u7684\u676d\u5dde\u5927\u5b66\u751f\u7269\u7cfb(\u73b0\u4e3a\u6d59\u5927\u751f\u79d1\u9662)\u3001\u4e2d\u79d1\u9662\u7ec6\u80de\u6240\u4ee5\u53ca\u4e9a\u5229\u6851\u90a3\u5dde\u7acb\u5927\u5b66\u63a5\u53d7\u4e86\u826f\u597d\u7684\u751f\u7269\u5b66\u57f9\u517b\uff0c\u4f46\u662f\u5bf9\u4e8e\u6c27\u611f\u77e5\u56e0\u5b50\u8fd9\u4e2a\u6311\u6218\u6027\u7684\u8bfe\u9898\u6839\u672c\u4e0d\u6562\u8f7b\u654c\u3002\u56e0\u4e3a\u4f60\u4e0d\u77e5\u9053\u8fd9\u4e2a\u5e7d\u7075\u662f\u4ec0\u4e48\uff0c\u600e\u4e48\u6837\u624d\u4f1a\u73b0\u8eab\uff0c\u5fc5\u987b\u8981\u505a\u5927\u91cf\u7684\u5b9e\u9a8c\u6761\u4ef6\uff0c\u628a\u5b83\u903c\u51fa\u6765\u3002\u6240\u4ee5\uff0c\u90a3\u4e2a\u65f6\u4ee3\uff0cJohns Hopkins\u5927\u5b66\u4eba\u7c7b\u9057\u4f20\u6240\u5b9e\u9a8c\u697c\u7684\u5b66\u751f\u5b66\u8005\u4eec\uff0c\u603b\u662f\u80fd\u5728\u5404\u5904\u770b\u5230\u4e00\u58f0\u4e0d\u542d\u3001\u57cb\u5934\u5b9e\u9a8c\u7684\u738b\u5e7f\u826f\u535a\u58eb\u3002\u5148\u505a\u4ec0\u4e48\uff0c\u540e\u505a\u4e2a\u4ec0\u4e48\uff0c\u65f6\u95f4\u95f4\u9699\u7a7f\u63d2\u7740\u505a\u4ec0\u4e48\uff0c\u738b\u535a\u58eb\u5176\u5b9e\u65e9\u5df2\u80f8\u6709\u6210\u7af9\u3002
<\/p>
\u6c27\u611f\u77e5\u56e0\u5b50HIF1\u663e\u5f62<\/strong>
<\/p>
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<\/p>
$\"\"\/$
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<\/figcaption><\/figure>
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1994\u5e748\u6708\uff0c\u5728\u548c\u738b\u5e7f\u826f\u5546\u8bae\u4e4b\u540e\uff0cSemenza \u6559\u6388\u51b3\u5b9a\u62db\u6536\u4ed6\u7684\u7b2c\u4e8c\u4e2a\u535a\u58eb\u540e\u3002\u6216\u8bb8\u662f\u4ece\u738b\u5e7f\u826f\u535a\u58eb\u8eab\u4e0a\u611f\u53d7\u5230\u4e86\u4e2d\u56fd\u5b66\u8005\u7684\u806a\u660e\u52e4\u594b\uff0cSemenza \u6559\u6388\u5728\u4f17\u591a\u5019\u9009\u4eba\u4e2d\u518d\u4e00\u6b21\u6311\u4e2d\u4e86\u4e00\u4f4d\u4e2d\u56fd\u5b66\u8005\u6c5f\u535a\u58eb(Binghua Jiang) \u6765\u534f\u52a9\u8fd9\u4e2a\u8bfe\u9898\uff0c\u5b8c\u6210\u8fd9\u4e9b\u8017\u65f6\u8d39\u529b\u7684\u5de5\u4f5c\u3002\u4eba\u591a\u529b\u91cf\u5927\uff0c\u901f\u5ea6\u66f4\u5feb\uff0c\u8fde\u6280\u672f\u5458Elizabeth Rue\u4e5f\u52a0\u5165\u8fd9\u4e2a\u62a2\u65f6\u95f4\u7684\u5de5\u4f5c\u4e2d\u3002\u5728\u4ed6\u4eec\u5171\u540c\u7684\u52aa\u529b\u4e0b\uff0c\u7b5b\u9009\u5230HIF1\u7684\u9633\u6027\u514b\u9686\uff0cHIF1\u57fa\u56e0\u7684DNA\u5e8f\u5217\u88ab\u6beb\u65e0\u60ac\u5ff5\u7684\u6d4b\u5b9a\uff0c\u8fd9\u662f1994\u5e74\u768412\u6708\uff0c\u53c8\u4e00\u4e2a\u6574\u5e74\u8fc7\u53bb\u4e86\u3002\u8fd9\u4e24\u5e74\u7684\u6210\u679c\u88ab\u6574\u7406\u597d\u53d1\u8868\u57281995\u5e746\u6708\u7684\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520a\u548cJournal of Biological Chemistry \u4e0a\u4e86\u3002\u8fd9\u53c8\u662f\u4e24\u7bc7\u6ce8\u5b9a\u9752\u53f2\u7559\u540d\u7684\u5927\u4f5c\uff0c\u4e25\u8c28\u53c8\u4e25\u8083\u7684Semenza \u6559\u6388\u5b9e\u4e8b\u6c42\u662f\u7684\u80af\u5b9a\u4e86\u6bcf\u4e00\u4e2a\u53c2\u4e0e\u8005\u7684\u8d21\u732e\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u90fd\u662f\u5f53\u4e4b\u65e0\u6127\u7684\u7b2c\u4e00\u8d21\u732e\u4eba\u3002\u7406\u6240\u5f53\u7136\u7684\uff0c\u8fd9\u4e00\u7bc7PNAS\u8bba\u6587\u4e5f\u6210\u4e3a\u8bfa\u8d1d\u5c14\u5956\u8bc4\u5ba1\u4f9d\u636e\u4e4b\u4e00, JBC\u8bba\u6587\u6210\u4e3a\u79d1\u5b66\u4ecb\u7ecd\u7684\u5f15\u6587\u4e4b\u4e00\u3002
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**\u4e8c\u5341\u5e74\u5e08\u5f92\u5408\u4f5c<\/strong><\/p>**

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**<\/p>**
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\u5728Semenza \u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u7684\u738b\u5e7f\u826f\u535a\u58eb
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\u5728\u7cfb\u7edf\u800c\u7a81\u7834\u6027\u7684\u5de5\u4f5c\u5b8c\u6210\u540e\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u62b1\u5b9a\u8981\u5c06HIF1\u4ea7\u4e1a\u5316\u7684\u96c4\u5fc3\uff0c\u4e8e1996\u5e74\u53bb\u5236\u836f\u516c\u53f8\u5de5\u4f5c\u3002\u4e00\u6b65\u4e00\u6b65\u4ece\u5b9e\u9a8c\u5ba4\u57fa\u7840\u7814\u7a76\u4eba\u5458\uff0c\u6210\u957f\u4e3a\u77e5\u540d\u836f\u4f01\u7684\u8d44\u6df1\u7814\u53d1\u9886\u8896\u30022005\u81f32006\u5e74\u95f4\uff0c\u5728Semenza \u6559\u6388\u76db\u60c5\u9080\u8bf7\u4e0b\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u53c8\u4ee5\u7814\u7a76\u5458\u804c\u4f4d(Scientist)\u56deJohns Hopkins \u533b\u5b66\u9662Semenza\u5b9e\u9a8c\u5ba4\u505a\u4e73\u817a\u764c\u836f\u7269\u7b5b\u9009\u7684\u8bfe\u9898\uff0c\u5efa\u7acb\u4e86\u4f53\u5916\u7b5b\u9009\u7cfb\u7edf\u30022017\u5e74\u524d\u540e\uff0c\u5df2\u662fOtsuka\u7f8e\u56fd\u5236\u836f\u516c\u53f8\u7814\u53d1\u9ad8\u7ba1\u7684\u738b\u5e7f\u826f\u535a\u58eb\u53c8\u4e00\u6b21\u548cSemenza \u6559\u6388\u5408\u4f5c\uff0c\u5e0c\u671b\u5728\u4e2d\u56fd\u878d\u8d44\u5f00\u53d1HIF1\u76f8\u5173\u836f\u7269\uff0c\u4f46\u56e0\u79cd\u79cd\u539f\u56e0\uff0c\u76f8\u5173\u6295\u8d44\u673a\u6784\u5bf9HIF1\u4e86\u89e3\u6709\u9650\uff0c\u672a\u80fd\u6210\u529f\uff0c\u4f46\u662f\u5bf9\u4e8e\u5408\u4f5c\u5171\u540c\u63a8\u8fdbHIF1\u7b49\u76f8\u5173\u9776\u70b9\u5728\u75be\u75c5\u7684\u533b\u836f\u4ea7\u4e1a\u5316\u7684\u51b3\u5fc3\u548c\u4fe1\u5ff5\u4ecd\u5b58\u3002\u738b\u535a\u58eb\u5206\u6790\uff0cHIF1\u5728\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u773c\u5e95\u75c5\uff0c\u751a\u81f3\u6108\u4f24\u3001\u518d\u751f\u3001\u514d\u75ab\u7b49\u65b9\u9762\uff0c\u90fd\u6781\u6709\u53ef\u80fd\u6709\u5e94\u7528\u3002
<\/p>
\u540e\u8bb0<\/strong>
<\/p>
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**<\/p>**
**\u53c2\u8003\u6587\u732e<\/p>**
Semenza, G.L., and Wang, G.L<\/strong>. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12, 5447-5454.
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Wang, G.L.,<\/strong> and Semenza, G.L. (1993). General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA.
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Wang, G.L.,<\/strong> and Semenza, G.L. (1995). Purification and characterization of hypoxia-inducible factor 1. Journal of Biological Chemistry.
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Wang, G.L.,<\/strong> Jiang, B.H., Rue, E.A., and Semenza, G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA.
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Ahmed F. Profile of Gregg L. Semenza. (2010). Proc Natl Acad Sci USA.
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**Semenza G.L. Serendipity, Generosity, and Inspiration. (2016). Cell. <\/p>**
**<\/p>**
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<\/figcaption><\/figure>
<\/p>
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\u4e00\u9879\u6210\u679c\u8bde\u751f\u4e4b\u524d\u5c31\u5f80\u5f80\u6709\u5f88\u591a\u5b66\u8005\u4e3a\u4e4b\u6218\u6597\uff0c\u6c27\u611f\u77e5\u56e0\u5b50\u7684\u53d1\u73b0\u66f4\u662f\u5982\u6b64\uff0c\u4e16\u754c\u8303\u56f4\u5185\u5df1\u6709\u591a\u5bb6\u5b9e\u9a8c\u5ba4\u4e0b\u51b3\u5fc3\u627e\u51fa\u8fd9\u4e2a\u5e7d\u7075\u822c\u7684\u5b58\u5728\u3002\u4e3a\u4ec0\u4e48\u662f\u738b\u5e7f\u826f\u800c\u4e0d\u662f\u522b\u4eba\uff0c\u7b2c\u4e00\u4e2a\u767b\u9876\uff0c\u7acb\u4e0b\u9996\u529f\uff1f
<\/p>
\u8ba9\u6211\u4eec\u628a\u76ee\u5149\u8f6c\u56de\u523028\u5e74\u524d\u7684\u90a3\u4e2a\u51ac\u5929\uff0c\u770b\u770b\u3002\u5e74\u8f7b\u7684Gregg Semenza \u535a\u58eb\u62ff\u5230\u4e86\u4e24\u9879\u79d1\u7814\u57fa\u91d1\uff0c\u5728\u8457\u540d\u7684Johns Hopkins \u5927\u5b66\u6210\u4e3a\u4e86\u52a9\u7406\u6559\u6388\uff0c\u65b0\u5f00\u4e86\u5c5e\u4e8e\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u66fe\u8bf4\u8fc7\u4ed6\u8fd9\u662f\u6781\u7aef\u7684\u5e78\u8fd0(extremely fortunate) \u3002\u7136\u800c\u4ed6\u5f53\u65f6\u6ca1\u6599\u5230\u662f\uff0c\u66f4\u5927\u7684\u8fd0\u6c14\u8fd8\u4f1a\u964d\u4e34\u5230\u4ed6\u8eab\u4e0a\u3002\u4ed6\u62db\u5230\u4e86\u4ed6\u804c\u4e1a\u751f\u6daf\u4e2d\u7684\u7b2c\u4e00\u4e2a\u535a\u58eb\u540e\uff0c\u540e\u6765\u88ab\u4ed6\u53cd\u590d\u79f0\u8d5e\u4e3a\u6770\u51fa\u79d1\u5b66\u5bb6(fabulous scientist) \u7684\u738b\u5e7f\u826f\u535a\u58eb\u3002
<\/p>
1992\u5e741\u6708\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u6b63\u5f0f\u52a0\u76dfSemenza \u5b9e\u9a8c\u5ba4\uff0c\u5171\u540c\u641c\u5bfb\u90a3\u4e2a\u80fd\u611f\u77e5\u6c27\u6c14\uff0c\u8c03\u8282\u8840\u7ea2\u7ec6\u80de\u751f\u6210\u7d20EPO\u7684\u795e\u79d8\u5e7d\u7075\u3002\u4e00\u95f4\u5c0f\u5c0f\u7684\u5b9e\u9a8c\u5ba4\uff0c\u51e0\u4e2a\u8001\u65e7\u4eea\u5668\uff0c\u4e00\u4e2a\u7565\u663e\u7a1a\u5ae9\u7684\u5e74\u8f7b\u6559\u6388\uff0c\u4e00\u4e2a\u5145\u6ee1\u5e72\u52b2\u7684\u65b0\u79d1\u535a\u58eb\uff0c\u5728\u90a3\u4e2a\u5bd2\u51ac\u5c31\u5168\u529b\u542f\u52a8\u4e86\u3002\u738b\u5e7f\u826f\u535a\u58eb\u81f3\u4eca\u8fd8\u8bb0\u5f97\u6700\u521d\u4e00\u4e24\u4e2a\u6708\u7684\u65f6\u5149\uff0c\u7ecf\u5e38\u6027\u7684\u501f\u522b\u4eba\u7684\u4eea\u5668\u501f\u4e0d\u5230\uff0c\u5b9e\u9a8c\u5ba4\u5c31\u53ea\u6709\u4ed6\u4eec\u5e08\u5f92\u4e8c\u4eba\u3002\u6ca1\u6709\u5b9e\u9a8c\uff0c\u4ed6\u4fe9\u4fbf\u5728\u5b9e\u9a8c\u53f0\u524d\u7528\u7eb8\u7b14\u89c4\u5212\u7740\u5b9e\u9a8c\u548c\u65f6\u95f4\uff0c\u4e24\u4eba\u751a\u81f3\u4e3a\u4e86\u5bf9\u7167\u5b9e\u9a8c\u548c\u68c0\u6d4b\u65b9\u6848\u4e89\u8bba\u7684\u9762\u7ea2\u8033\u8d64\u3002\u6b63\u662f\u8fd9\u6bb5\u4e0d\u5bb9\u6613\u52a8\u624b\u505a\u5b9e\u9a8c\u7684\u65f6\u5149\uff0c\u953b\u9020\u4e86\u4e25\u8c28\u7684\u79d1\u7814\u89c4\u5212\u548c\u5b9e\u9a8c\u65b9\u6848\u3002\u6b63\u662f\u8fd9\u6837\u53cd\u590d\u7684\u8fa8\u6790\uff0c\u738b\u5e7f\u826f\u5bf9\u641c\u5bfb\u6c27\u611f\u77e5\u56e0\u5b50\u6709\u4e86\u7cfb\u7edf\u6027\u7684\u601d\u8003\uff0c\u4f7f\u5f97\u4ed6\u5728\u4ee5\u540e\u7684\u5b9e\u9a8c\u4e2d\u8033\u806a\u76ee\u660e\uff0c\u5fc3\u7075\u624b\u5de7\uff0c\u4ee5\u6700\u5c11\u7684\u8bef\u64cd\u4f5c\uff0c\u8fc5\u901f\u6210\u529f\u3002
<\/p>
\u738b\u5e7f\u826f\u535a\u58eb\u540e\u6765\u603b\u7ed3\uff0c\u4e00\u95e8\u5fc3\u601d\u7684\u82e6\u5e72\uff0c\u4e5f\u662f\u539f\u521b\u6027\u5de5\u4f5c\u5fc5\u987b\u7684\u3002\u867d\u7136\u738b\u5e7f\u826f\u5728\u4e2d\u56fd\u8457\u540d\u7684\u676d\u5dde\u5927\u5b66\u751f\u7269\u7cfb(\u73b0\u4e3a\u6d59\u5927\u751f\u79d1\u9662)\u3001\u4e2d\u79d1\u9662\u7ec6\u80de\u6240\u4ee5\u53ca\u4e9a\u5229\u6851\u90a3\u5dde\u7acb\u5927\u5b66\u63a5\u53d7\u4e86\u826f\u597d\u7684\u751f\u7269\u5b66\u57f9\u517b\uff0c\u4f46\u662f\u5bf9\u4e8e\u6c27\u611f\u77e5\u56e0\u5b50\u8fd9\u4e2a\u6311\u6218\u6027\u7684\u8bfe\u9898\u6839\u672c\u4e0d\u6562\u8f7b\u654c\u3002\u56e0\u4e3a\u4f60\u4e0d\u77e5\u9053\u8fd9\u4e2a\u5e7d\u7075\u662f\u4ec0\u4e48\uff0c\u600e\u4e48\u6837\u624d\u4f1a\u73b0\u8eab\uff0c\u5fc5\u987b\u8981\u505a\u5927\u91cf\u7684\u5b9e\u9a8c\u6761\u4ef6\uff0c\u628a\u5b83\u903c\u51fa\u6765\u3002\u6240\u4ee5\uff0c\u90a3\u4e2a\u65f6\u4ee3\uff0cJohns Hopkins\u5927\u5b66\u4eba\u7c7b\u9057\u4f20\u6240\u5b9e\u9a8c\u697c\u7684\u5b66\u751f\u5b66\u8005\u4eec\uff0c\u603b\u662f\u80fd\u5728\u5404\u5904\u770b\u5230\u4e00\u58f0\u4e0d\u542d\u3001\u57cb\u5934\u5b9e\u9a8c\u7684\u738b\u5e7f\u826f\u535a\u58eb\u3002\u5148\u505a\u4ec0\u4e48\uff0c\u540e\u505a\u4e2a\u4ec0\u4e48\uff0c\u65f6\u95f4\u95f4\u9699\u7a7f\u63d2\u7740\u505a\u4ec0\u4e48\uff0c\u738b\u535a\u58eb\u5176\u5b9e\u65e9\u5df2\u80f8\u6709\u6210\u7af9\u3002
<\/p>
\u6c27\u611f\u77e5\u56e0\u5b50HIF1\u663e\u5f62<\/strong>
<\/p>
\u5f53\u65f6\u8840\u7ea2\u7ec6\u80de\u751f\u6210\u7d20EPO\u5df1\u7ecf\u53ef\u4ee5\u68c0\u6d4b\uff0c\u4f46\u662f\u4ec0\u4e48\u56e0\u5b50\u7ed3\u5408\u5230\u5b83\u8eab\u4e0a\uff0c\u611f\u53d7\u6c27\u6c14\u5462\uff1f\u600e\u4e48\u624d\u80fd\u770b\u5230\u5b83\uff1f\u738b\u535a\u58eb\u5f00\u59cb\u4e86\u6700\u575a\u82e6\u7684\u641c\u7d22\u8fc7\u7a0b\uff0c\u4ed6\u8bbe\u8ba1\u4e86\u5927\u91cf\u7684\u63a2\u9488\uff0c\u53d8\u6362\u5404\u79cd\u53ef\u80fd\u7684\u6eb6\u6db2\u6761\u4ef6\uff0c\u505aGel shift\u7684\u80f6\u7247\u5728\u5b9e\u9a8c\u684c\u4e0a\u90fd\u5806\u8d77\u4e86\u4e00\u5ea7\u5c0f\u5c71\u3002\u6ca1\u6709\u8fd0\u6c14\uff0c\u4e5f\u6ca1\u770b\u5230\u4ec0\u4e48\u660e\u663e\u7684\u7ed3\u679c\uff0c\u600e\u4e48\u529e\uff1f\u975e\u5e38\u82e6\u95f7\u7684\u738b\u5e7f\u826f\u548c\u540c\u6837\u82e6\u95f7\u7684Semenza\u6559\u6388\u5f00\u59cb\u9759\u4e0b\u5fc3\u6765\uff0c\u4e00\u5f20\u5f20\u80f6\u7247\u6bd4\u5bf9\uff0c\u68c0\u9605\u3002\u5ffd\u7136\uff0c\u4e00\u5f20\u80f6\u7247\u8ba9\u4ed6\u4eec\u773c\u524d\u4e00\u4eae\uff0cSemenza \u6559\u6388\u773c\u5c16\u5634\u5feb\uff0c\u5927\u53eb\u5230 :\u201c\u5e7f\u826f\uff0c\u4f60\u770b\u89c1\u4e86\u5417\uff1f\u8fd9\u597d\u50cf\u6709\u4e2a\u4e0d\u5bfb\u5e38\u7684\u86cb\u767d\u6761\u5e26\u201d\u3002\u738b\u5e7f\u826f\u7acb\u523b\u5fc3\u9886\u795e\u4f1a\uff0c\u548c\u5176\u5b83\u80f6\u7247\u4e00\u6bd4\u5bf9\uff0c\u679c\u7136\u8fd9\u6761\u6709\u6f02\u79fb\uff01Semenza \u6559\u6388\u5174\u594b\u4e86\uff0c\u770b\u4e86\u80f6\u7247\u4e0a\u8bb0\u5f55\u7684\u8be6\u7ec6\u4e25\u8c28\u7684\u5b9e\u9a8c\u6761\u4ef6\uff0c\u8fde\u58f0\u79f0\u8d5e: \u201c\u4f60\u592a\u68d2\u4e86\uff01\u201d \u3002
<\/p>
$\"\"\/$
\u738b\u5e7f\u826f\u535a\u58eb\u7b2c\u4e00\u6b21\u6355\u6349\u5230HIF1\u7684\u80f6\u7247
<\/figcaption><\/figure>
\u4e8b\u60c5\u51fa\u73b0\u8f6c\u673a\uff0c\u4ed6\u4eec\u5728\u4f9d\u636e\u738b\u5e7f\u826f\u8be6\u7ec6\u8bb0\u5f55\u7684\u8bd5\u9a8c\u6761\u4ef6\uff0c\u8bbe\u4e86\u51e0\u79cd\u65b0\u7684\u6539\u8fdb\u7684\u6761\u4ef6\uff0c\u7ee7\u7eed\u8bd5\u9a8c\uff0c\u6700\u7ec8\u67f3\u6697\u82b1\u660e\uff0c\u8eb2\u5728\u566a\u97f3\u80cc\u666f\u4e2d\u7684\u6c27\u611f\u77e5\u56e0\u5b50\u663e\u5f62\u4e86\uff01\u5f53\u6e05\u6670\u7684\u6761\u5e26\u5c55\u793a\u5728Semenza \u6559\u6388\u684c\u4e0a\u65f6\uff0c\u4ed6\u6fc0\u52a8\u7684\u8bf4:\u201c\u8fd9\u662f\u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684\u6c27\u611f\u77e5\u56e0\u5b50\uff0c\u8ba9\u6211\u4eec\u628a\u5b83\u547d\u540d\u4e3aHIF-1\u5427\u201d\uff01\u968f\u540e\uff0cSemenza \u6559\u6388\u8fc5\u901f\u64b0\u5199\u8bba\u6587\uff0c\u548c\u738b\u5e7f\u826f\u4e24\u4e2a\u4eba\u4e00\u8d77\u5728\u6743\u5a01\u6742\u5fd7Mol Cell Biol \u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u5411\u5168\u4e16\u754c\u5ba3\u544aHIF1\u7684\u53d1\u73b0\u3002\u6587\u7ae0\u53d1\u8868\u65f6\u671f\u662f1992\u5e7412\u6708\uff0c\u8ddd\u738b\u5e7f\u826f\u52a0\u5165Semenza \u5b9e\u9a8c\u5ba4\u51e0\u4e4e\u4e00\u5e74\u6574\u3002\u62ff\u4e86\u4e00\u4e2a\u4e16\u754c\u7b2c\u4e00\uff0c\u8fd9\u4e00\u5e74\u4ed6\u5c31\u505a\u4e86\u8fd9\u4e00\u4ef6\u4e8b\u300227\u5e74\u540e\uff0c\u6210\u4e3a\u8bfa\u8d1d\u5c14\u5956\u79d1\u5b66\u4ecb\u7ecd\u5f15\u7528\u8bba\u6587\u4e4b\u4e00\u3002
<\/p>
HIF1\u86cb\u767d\u663e\u5f62\uff0c\u63a5\u7740\u5c31\u662f\u7eaf\u5316\u9274\u5b9a\u4e86\u3002\u51e0\u767e\u5347\u7684\u7ec6\u80de\u6447\u8d77\u6765\uff0c\u770b\u7740\u8d8a\u6765\u8d8a\u6d53\u7684\u6eb6\u6db2\uff0c\u738b\u535a\u58eb\u5df2\u5b8c\u5168\u89c4\u5212\u597d\u4e0b\u4e00\u6b65\u3002\u4ed6\u5f88\u5feb\u53c8\u63d0\u7740\u5927\u7f50\u7ec6\u80de\uff0c\u5404\u7c7b\u8bd5\u5242\uff0c\u88f9\u4e0a\u5927\u68c9\u8884\uff0c\u4e00\u5934\u94bb\u8fdb\u53ea\u67094\u6444\u6c0f\u5ea6\u7684\u51b7\u5ba4\u53bb\u63d0\u53d6\u86cb\u767d\u3002\u5f53\u51e0\u767e\u5347\u7684\u7ec6\u80de\u6700\u7ec8\u53d8\u6210\u51e0\u4e2a\u6beb\u514b\u7684HIF1\u86cb\u767d, \u738b\u5e7f\u826f\u7b11\u4e86\uff01\u4e00\u4e2a\u4eba\u505a\u4e86\u8fd9\u4e48\u4e45\u7684\u5b9e\u9a8c\uff0c\u7ec8\u4e8e\u628a\u8fd9\u4e2a\u5e7d\u7075\u7eaf\u5316\u5206\u79bb\u51fa\u6765\u4e86\uff0c\u592a\u5b9d\u8d35\u4e86\u3002\u53ef\u522b\u5c0f\u770b\u8fd9\u4e2a\u8d39\u65f6\u8d39\u529b\u7684\u7eaf\u5316\u8fc7\u7a0b\uff0c\u597d\u591a\u7ade\u4e89\u5bf9\u624b\u5c31\u662f\u60f3\u5f2f\u9053\u8d85\u8f66\uff0c\u7701\u7565\u8fd9\u4e2a\u6b65\u9aa4\uff0c\u53e6\u8d70\u5176\u5b83\u6240\u8c13\u6377\u5f80\uff0c\u800c\u6700\u7ec8\u529f\u8d25\u5782\u6210\u30021993\u5e74\uff0c\u738b\u5e7f\u826f\u548cSemenza\u535a\u58eb\u4e24\u4e2a\u4eba\u5728\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520aPNAS\u4e0a\u53d1\u8868\u4e86 HIF1\u6c27\u611f\u77e5\u529f\u80fd\u7684\u8bba\u6587\uff0c\u8fd9\u7bc7\u6587\u7ae0\uff0c\u6210\u4e3a\u65e5\u540e\u8bfa\u8d1d\u5c14\u5956\u79d1\u5b66\u4ecb\u7ecd\u4e2d\u7684\u53c2\u8003\u6587\u732e\u3002\u8fd9\u5e74\u5e95\uff0cSemenza \u6559\u6388\u7ed9\u4e86\u4e00\u95e8\u5fc3\u601d\u505a\u7814\u7a76\u7684\u738b\u5e7f\u826f\u4e00\u4e2a\u664b\u5347\uff0c\u738b\u5e7f\u826f\u6b63\u5f0f\u6210\u4e3a Johns Hopkins\u5927\u5b66\u7684\u52a9\u7406\u7814\u7a76\u5458\u3002
<\/p>
\u63a5\u4e0b\u6765\uff0c\u5e38\u89c4\u7684\u6280\u672f\uff0c\u7528\u86cb\u767d\u9176\u628a\u5b83\u5207\u6210\u5c0f\u7247\u6bb5\u62ff\u53bb\u505a\u86cb\u767d\u6d4b\u5e8f\uff0c\u6839\u636e\u5f97\u5230\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u6765\u63a8\u5bfcDNA\u5e8f\u5217\uff0c\u5c31\u53ef\u4ee5\u628a\u63a8\u5bfc\u51fa\u6765\u7684DNA\u5e8f\u5217\u8bbe\u8ba1\u6210\u63a2\u9488\u4e86\u3002\u63a2\u9488\u8bbe\u8ba1\u5b8c\u6210\uff0c\u63a5\u4e0b\u6765\uff0c\u5c31\u5230\u57fa\u56e0\u5e93\u91cc\u9762\u53bb\u9493HIF\u57fa\u56e0, \u8981\u786e\u5b9a\u57fa\u56e0\u7684DNA\u5e8f\u5217\uff0c\u79cd\u79cd\u540e\u7eed\u5de5\u4f5c\uff0c\u738b\u535a\u58eb\u548cSemenza \u6559\u6388\u5df1\u65e9\u65e9\u8ba1\u5212\u597d\uff0c\u8fd8\u8981\u518d\u62ff\u4e16\u754c\u7b2c\u4e00\uff01\u867d\u7136\u8fd8\u6709\u5927\u91cf\u5de5\u4f5c\u8981\u505a\uff0c\u4f46\u662f\uff0c\u90a3\u66f4\u591a\u7684\u662f\u4f53\u529b\u6d3b\u4e86\u3002\u738b\u5e7f\u826f\u4e5f\u5f88\u5feb\u7684\u8bbe\u8ba1\u4e86\u63a2\u9488\uff0c\u51c6\u5907\u597d\u9493\u57fa\u56e0\u3002\u6b64\u65f6\u7684\u738b\u5e7f\u826f\u548cSemenza \u6559\u6388\u90fd\u5fc3\u60c5\u6109\u5feb\uff0c\u80dc\u5229\u518d\u671b\u4e86\u3002
<\/p>
1994\u5e748\u6708\uff0c\u5728\u548c\u738b\u5e7f\u826f\u5546\u8bae\u4e4b\u540e\uff0cSemenza \u6559\u6388\u51b3\u5b9a\u62db\u6536\u4ed6\u7684\u7b2c\u4e8c\u4e2a\u535a\u58eb\u540e\u3002\u6216\u8bb8\u662f\u4ece\u738b\u5e7f\u826f\u535a\u58eb\u8eab\u4e0a\u611f\u53d7\u5230\u4e86\u4e2d\u56fd\u5b66\u8005\u7684\u806a\u660e\u52e4\u594b\uff0cSemenza \u6559\u6388\u5728\u4f17\u591a\u5019\u9009\u4eba\u4e2d\u518d\u4e00\u6b21\u6311\u4e2d\u4e86\u4e00\u4f4d\u4e2d\u56fd\u5b66\u8005\u6c5f\u535a\u58eb(Binghua Jiang) \u6765\u534f\u52a9\u8fd9\u4e2a\u8bfe\u9898\uff0c\u5b8c\u6210\u8fd9\u4e9b\u8017\u65f6\u8d39\u529b\u7684\u5de5\u4f5c\u3002\u4eba\u591a\u529b\u91cf\u5927\uff0c\u901f\u5ea6\u66f4\u5feb\uff0c\u8fde\u6280\u672f\u5458Elizabeth Rue\u4e5f\u52a0\u5165\u8fd9\u4e2a\u62a2\u65f6\u95f4\u7684\u5de5\u4f5c\u4e2d\u3002\u5728\u4ed6\u4eec\u5171\u540c\u7684\u52aa\u529b\u4e0b\uff0c\u7b5b\u9009\u5230HIF1\u7684\u9633\u6027\u514b\u9686\uff0cHIF1\u57fa\u56e0\u7684DNA\u5e8f\u5217\u88ab\u6beb\u65e0\u60ac\u5ff5\u7684\u6d4b\u5b9a\uff0c\u8fd9\u662f1994\u5e74\u768412\u6708\uff0c\u53c8\u4e00\u4e2a\u6574\u5e74\u8fc7\u53bb\u4e86\u3002\u8fd9\u4e24\u5e74\u7684\u6210\u679c\u88ab\u6574\u7406\u597d\u53d1\u8868\u57281995\u5e746\u6708\u7684\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u520a\u548cJournal of Biological Chemistry \u4e0a\u4e86\u3002\u8fd9\u53c8\u662f\u4e24\u7bc7\u6ce8\u5b9a\u9752\u53f2\u7559\u540d\u7684\u5927\u4f5c\uff0c\u4e25\u8c28\u53c8\u4e25\u8083\u7684Semenza \u6559\u6388\u5b9e\u4e8b\u6c42\u662f\u7684\u80af\u5b9a\u4e86\u6bcf\u4e00\u4e2a\u53c2\u4e0e\u8005\u7684\u8d21\u732e\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u90fd\u662f\u5f53\u4e4b\u65e0\u6127\u7684\u7b2c\u4e00\u8d21\u732e\u4eba\u3002\u7406\u6240\u5f53\u7136\u7684\uff0c\u8fd9\u4e00\u7bc7PNAS\u8bba\u6587\u4e5f\u6210\u4e3a\u8bfa\u8d1d\u5c14\u5956\u8bc4\u5ba1\u4f9d\u636e\u4e4b\u4e00, JBC\u8bba\u6587\u6210\u4e3a\u79d1\u5b66\u4ecb\u7ecd\u7684\u5f15\u6587\u4e4b\u4e00\u3002
<\/p>
**\u4e8c\u5341\u5e74\u5e08\u5f92\u5408\u4f5c<\/strong><\/p>**

\u5728\u548cSemenza \u6559\u6388\u8054\u540d\u53d1\u8868\u4e86\u4e24\u7bc7\u5386\u53f2\u6027\u7684\u8457\u4f5c\u540e\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u53c8\u5728Semenza \u5b9e\u9a8c\u5ba4\u53c8\u5de5\u4f5c\u4e86\u4e00\u6bb5\u65f6\u95f4\u3002\u9274\u4e8e\u738b\u5e7f\u826f\u535a\u58eb\u540e\u671f\u95f4\u53d1\u8868\u7684\u4f17\u591a\u7cbe\u5f69\u6587\u7ae0\uff0c\u5f88\u591a\u5927\u5b66\u548c\u516c\u53f8\u5411\u738b\u5e7f\u826f\u4f38\u51fa\u4e86\u6a44\u6984\u679d\uff0c\u7ecf\u8fc7\u6df1\u601d\u719f\u8651\uff0c\u738b\u535a\u58eb\u51b3\u5b9a\u8fc8\u5411\u533b\u836f\u4ea7\u4e1a\u754c\uff0c\u5e0c\u671b\u5c06HIF1\u7684\u7814\u7a76\u4ece\u57fa\u7840\u751f\u7269\u5b66\u63a8\u5411\u533b\u836f\u3002
<\/p>
**<\/p>**
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\u5728Semenza \u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u7684\u738b\u5e7f\u826f\u535a\u58eb
<\/figcaption><\/figure>
\u5728\u7cfb\u7edf\u800c\u7a81\u7834\u6027\u7684\u5de5\u4f5c\u5b8c\u6210\u540e\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u62b1\u5b9a\u8981\u5c06HIF1\u4ea7\u4e1a\u5316\u7684\u96c4\u5fc3\uff0c\u4e8e1996\u5e74\u53bb\u5236\u836f\u516c\u53f8\u5de5\u4f5c\u3002\u4e00\u6b65\u4e00\u6b65\u4ece\u5b9e\u9a8c\u5ba4\u57fa\u7840\u7814\u7a76\u4eba\u5458\uff0c\u6210\u957f\u4e3a\u77e5\u540d\u836f\u4f01\u7684\u8d44\u6df1\u7814\u53d1\u9886\u8896\u30022005\u81f32006\u5e74\u95f4\uff0c\u5728Semenza \u6559\u6388\u76db\u60c5\u9080\u8bf7\u4e0b\uff0c\u738b\u5e7f\u826f\u535a\u58eb\u53c8\u4ee5\u7814\u7a76\u5458\u804c\u4f4d(Scientist)\u56deJohns Hopkins \u533b\u5b66\u9662Semenza\u5b9e\u9a8c\u5ba4\u505a\u4e73\u817a\u764c\u836f\u7269\u7b5b\u9009\u7684\u8bfe\u9898\uff0c\u5efa\u7acb\u4e86\u4f53\u5916\u7b5b\u9009\u7cfb\u7edf\u30022017\u5e74\u524d\u540e\uff0c\u5df2\u662fOtsuka\u7f8e\u56fd\u5236\u836f\u516c\u53f8\u7814\u53d1\u9ad8\u7ba1\u7684\u738b\u5e7f\u826f\u535a\u58eb\u53c8\u4e00\u6b21\u548cSemenza \u6559\u6388\u5408\u4f5c\uff0c\u5e0c\u671b\u5728\u4e2d\u56fd\u878d\u8d44\u5f00\u53d1HIF1\u76f8\u5173\u836f\u7269\uff0c\u4f46\u56e0\u79cd\u79cd\u539f\u56e0\uff0c\u76f8\u5173\u6295\u8d44\u673a\u6784\u5bf9HIF1\u4e86\u89e3\u6709\u9650\uff0c\u672a\u80fd\u6210\u529f\uff0c\u4f46\u662f\u5bf9\u4e8e\u5408\u4f5c\u5171\u540c\u63a8\u8fdbHIF1\u7b49\u76f8\u5173\u9776\u70b9\u5728\u75be\u75c5\u7684\u533b\u836f\u4ea7\u4e1a\u5316\u7684\u51b3\u5fc3\u548c\u4fe1\u5ff5\u4ecd\u5b58\u3002\u738b\u535a\u58eb\u5206\u6790\uff0cHIF1\u5728\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u773c\u5e95\u75c5\uff0c\u751a\u81f3\u6108\u4f24\u3001\u518d\u751f\u3001\u514d\u75ab\u7b49\u65b9\u9762\uff0c\u90fd\u6781\u6709\u53ef\u80fd\u6709\u5e94\u7528\u3002
<\/p>
\u540e\u8bb0<\/strong>
<\/p>
\u672c\u5468\u4ee5\u6765\uff0c\u534e\u76db\u987f\u6d59\u5927\u6821\u53cb\u4f1a\u8bb0\u8005\u4e24\u6b21\u4e13\u8bbf\u4e86\u738b\u5e7f\u826f\u535a\u58eb\uff0c\u53d6\u5f97\u5f88\u591a\u72ec\u5bb6\u8d44\u6599\u3002\u8bb0\u8005\u5728\u91c7\u8bbf\u3001\u8c03\u7814\u8fc7\u7a0b\u4e2d\uff0c\u4e5f\u6df1\u6df1\u7684\u4e3a\u738b\u535a\u58eb\u5236\u836f\u6cbb\u75c5\u7684\u60c5\u6000\u800c\u611f\u52a8\uff0c\u66f4\u4e3a\u4ed6\u5bf9\u4eba\u5bf9\u4e8b\u7684\u4e00\u7247\u8d64\u5b50\u4e4b\u5fc3\u800c\u611f\u52a8\u3002\u6211\u4eec\u611f\u8c22\uff0c\u534e\u4eba\u5b66\u8005\u4e2d\uff0c\u6709\u738b\u5e7f\u826f\u535a\u58eb\u8fd9\u6837\u4e00\u6279\u7cbe\u901a\u4ece\u5b9e\u9a8c\u5ba4\u7814\u7a76\u5230\u4ea7\u4e1a\u7814\u53d1\u4e00\u6574\u5957\u4ea7\u5b66\u7814\u8def\u7ebf\u7684\u7cbe\u82f1\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u53ea\u8981\u6709\u201c\u6c42\u662f\u7cbe\u795e\u201d\uff0c\u4e0d\u8bba\u662f\u8bfa\u8d1d\u5c14\u5956\uff0c\u8fd8\u662f\u9ad8\u79d1\u6280\u4ea7\u4e1a\uff0c\u534e\u4eba\u7684\u540d\u5b57\u5fc5\u5c06\u4e0d\u65ad\u6d8c\u73b0\uff01<\/p>
**<\/p>**
**\u53c2\u8003\u6587\u732e<\/p>**
Semenza, G.L., and Wang, G.L<\/strong>. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12, 5447-5454.
<\/p>
Wang, G.L.,<\/strong> and Semenza, G.L. (1993). General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA.
<\/p>
Wang, G.L.,<\/strong> and Semenza, G.L. (1995). Purification and characterization of hypoxia-inducible factor 1. Journal of Biological Chemistry.
<\/p>
Wang, G.L.,<\/strong> Jiang, B.H., Rue, E.A., and Semenza, G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA.
<\/p>
Ahmed F. Profile of Gregg L. Semenza. (2010). Proc Natl Acad Sci USA.
<\/p>
**Semenza G.L. Serendipity, Generosity, and Inspiration. (2016). Cell. <\/p>**
**<\/p>**
**<\/p>","protected":false},"excerpt":{"rendered":"**
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